Branson Sonifier 450 Analog Ultrasonic Cell Disruptor 117VAC 4A w/ Converter

Branson Sonifier 450 Analog Ultrasonic Cell Disruptor 117VAC 4A w/ Converter Probe

The Branson Sonifier 450 is an analog benchtop ultrasonic liquid processor used for cell disruption, homogenization, emulsification, and related sample preparation tasks. It generates high-frequency ultrasonic energy through a piezoelectric converter, transmitting it via a titanium horn directly into the sample. Front-panel controls allow the operator to set timer duration, duty cycle (pulsed or continuous), and output level — making it adaptable across a wide range of sample volumes and sensitivities.

Specifications & What's Included

• Make: Branson Ultrasonics Corporation
• Model: Sonifier 450
• Part No.: 100-132-137
• Input: 117VAC, Single Phase, 4A, 50/60Hz
• Form factor: Benchtop, sloped front-panel design
• Timer: 0–15 minutes variable + Hold (continuous) mode
• Duty cycle: 10–90% pulsed + Constant mode
• Output control: 1–10 dial with Micro Tip Limit setting
• Output display: Analog 0–100% meter on front panel
• Power switch: On/Off rocker on front panel
• Rear connectors: Multi-pin circular RF cable port (TM-1), fuse holder (6A), line cord
• Converter: Branson Ultrasonics piezoelectric handpiece converter
• Horn / probe: 1/2-inch tapered titanium tip
• Converter cable: Coaxial RF cable connecting converter to main unit
• Country of manufacture: USA (Branson Ultrasonics Corporation, Danbury, CT)

Applications

The Branson Sonifier 450 is a widely used instrument in biological and chemical research labs. It is used for cell disruption and lysis (releasing intracellular contents from bacteria, yeast, and mammalian cells), preparation of DNA and protein samples, nanoparticle dispersion, emulsification, and solvent degassing. The pulsed-mode operation makes it well suited for thermally sensitive samples where continuous sonication would cause excessive heat buildup. The 450 model has been a standard in molecular biology and biochemistry labs since the 1980s and remains in widespread use today in university, pharmaceutical, biotech, and industrial research environments. Sample volumes from 1 mL up to several hundred mL can be processed by swapping horn tips, making it one of the more versatile bench-top sonicators in its class. Units like this one are frequently found in academic and commercial biotech labs and remain in demand on the secondary market due to Branson's long-standing reputation for reliability in ultrasonic processing equipment.